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. 2023 Jan 5;3(1):20220045. doi: 10.1002/EXP.20220045

FIGURE 4.

FIGURE 4

RBC‐hitchhiking system for delivering PS NMs to the spleen. (A) Schematic for the design of delivering PS NMs to the spleen through RBC hitchhiking. (B) SEM of PS NMs‐attached RBCs. (C) Release of PS NMs from RBCs following in vitro shear studies at a shear stress of 6 Pa, corresponding to the shear stress at lung capillaries. (D) In vivo imaging system images of the lungs and spleen collected 20 min after the administration of PS NMs–RBC hitchhiking at different ratios of NMs to RBC. Alexa Fluor 647‐labeled antigen‐coated NMs were used in this experiment. (E) Lung/spleen accumulation ratios calculated by using the fluorescence intensities of isolated lungs and spleen at different ratios of NM/RBC. Reproduced with permission.[ 73 ] Copyright 2020, National Academy of Sciences.