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. 2023 Jan 5;3(1):20220045. doi: 10.1002/EXP.20220045

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© 2023 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Magnetothermal manipulating the corona composition of circulated iron oxide nanoparticles (IONPs) and changing their distribution in the body. (A) Schematic diagram depicting magnetothermal regulation of the corona on circulated IONPs, wherein in situ corona regulation leads to downregulated opsonins and upregulated dysopsonins, which further decreases sequestration by the MPS. (B) The impact of in vivo magnetothermal regulation on the relative abundance of opsonins and dysopsonins (top 20 most abundant) on circulated IONPs. The IONPs without AMF treatment served as control. (C) Variation of the dysopsonin‐to‐opsonin ratios after magnetothermal regulation both in vitro and in vivo. Liver (D) and spleen (E) distribution of IONPs 12 h post‐injection with different treatments. AMF conditions: frequency, f = 345 kHz and magnetic field amplitude, H = 200, 250, and 300 Oe (AMF‐200, AMF‐250, and AMF‐300); duration, 15 min. Reproduced with permission.^[ ¹⁰⁴ ^] Copyright 2021, Elsevier.