Table 1.
Mutations detected in virus strains used in the experimental procedures.
| Strain | Nextclade_pango | Clade | Clade_WHO | a.a. Substitutions | a.a. Deletions |
|---|---|---|---|---|---|
| BA.1 | BA.1 | 21K | Omicron | E:T9I,M:A63T,N:P13L,N:R203K,N:G204R,ORF1a:R99C,ORF1a:K856R,ORF1a:S2083I,ORF1a:A2710T,ORF1a:T3255I,ORF1a:P3395H,ORF1a:I3758V,ORF1b:P314L,ORF1b:I1566V, ORF9b:P10S | N:E31-,N:R32-,N:S33-,ORF1a:S2084-,ORF1a:L3674-,ORF1a:S3675-,ORF1a:G3676-,ORF9b:E27-,ORF9b:N28-,ORF9b:A29- |
| BA.2 | BA.2 | 21L | Omicron | E:T9I,M:Q19E,M:A63T,N:P13L,N:R203K,N:G204R,N:S413R,ORF1a:S135R,ORF1a:T842I,ORF1a:G1307S,ORF1a:T1760A,ORF1a:T1881I,ORF1a:L3027F,ORF1a:T3255I,ORF1a:P3395H,ORF1a:I3758V,ORF1b:P314L,ORF1b:R1315C,ORF1b:I1566V,ORF1b:T2163I,ORF3a:T223I,ORF6:D61L,ORF9b:P10S | N:E31-,N:R32-,N:S33-,ORF1a:S3675-,ORF1a:G3676-,ORF1a:F3677-,ORF9b:E27-,ORF9b:N28-,ORF9b:A29- |
| BA.2-like | BA.2 | 21L | Omicron | E:T9I,M:Q19E,M:A63T,N:P13L,N:R203K,N:G204R,N:S413R,ORF1a:S135R,ORF1a:T842I,ORF1a:G1307S,ORF1a:P2018S,ORF1a:P2046S,ORF1a:T2800I,ORF1a:L3027F,ORF1a:L3201F,ORF1a:T3255I,ORF1a:P3395H,ORF1a:L3606F,ORF1a:T4311I,ORF1b:P314L,ORF1b:R1315C,ORF1b:I1566V,ORF1b:T2163I,ORF3a:T223I,ORF6:D61I,ORF9b:P10S | N:E31-,N:R32-,N:S33-,ORF1a:S3675-,ORF1a:G3676-,ORF1a:F3677-,ORF9b:E27-,ORF9b:N28-,ORF9b:A29- |
| BA.5 | BA.5.1.8 | 22B | Omicron | E:T9I,M:D3N,M:Q19E,M:A63T,N:P13L,N:R203K,N:G204R,N:S413R,ORF1a:S135R,ORF1a:T842I,ORF1a:G1307S,ORF1a:L3027F,ORF1a:T3090I,ORF1a:T3255I,ORF1a:P3395H,ORF1a:I3758V,ORF1a:T4161I,ORF1b:P314L,ORF1b:R1315C,ORF1b:I1566V,ORF1b:T2163I,ORF3a:T223I,ORF9b:P10S | N:E31-,N:R32-,N:S33-,ORF1a:S3675-,ORF1a:G3676-,ORF1a:F3677-,ORF9b:E27-,ORF9b:N28-,ORF9b:A29- |
List of mutations targeting viral genes, except those in the Spike protein, detected by Whole Genome Sequence (WGS) analysis of selected virus stocks used in all the experimental procedures. In bold, are shown non-common mutations in proteins with well-established antagonistic properties on innate immunity.