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. 2023 Mar 27;324(5):C1101–C1109. doi: 10.1152/ajpcell.00071.2023

Figure 1.

Figure 1.

miR-16 levels in overloaded muscle in vivo and RNA-sequencing (RNA-seq) analysis in proliferating C2C12 myoblasts 18 h after miR-16 knockdown (KD). A: miR-16 levels in plantaris skeletal muscle after 72 h of synergist ablation mechanical overload of the plantaris (MOV) relative to sham operation. B: in vitro study design. C: miR-16 levels in control and KD myoblasts. D: levels of ribosomal protein genes in control and KD myoblasts. E: levels of p53- and Pol II transcription-related genes in control and KD myoblasts. For RNA-seq experiments, n = 3 control and n = 2 KD technical replicates. *adj. P < 0.05.