Table 1.

Summary of data on systemic immune derangements in human or animal models among the pathologies discussed in this review

	Lymphopenia	T cell sequestration to the bone marrow	Splenic contraction	Thymic contraction	T cell dysfunction/ other (see notes)
Brain tumors	Patients Mouse models	Patients, Mouse models	Patients, Mouse Models	Mouse models	Delayed hypersensitivity, defects in activation, proliferation
Stroke	Patients Mouse models	Not reported	Patients Mouse models	Mouse models	Not reported
Multiple Sclerosis/EAE	Patients Mouse models (strain and time point dependant)	Not reported	Not reported in patients/Splenic T cell contraction reported in EAE, overall spleen atrophy depends on pathology, strain, and model	Patients (reduced TRECs =proxy) Mouse models (transient thymic involution in EAE)	Defects in CD8+ effector and memory responses Defects in Trges
TMEV/cuprizone-induced demyelination	Mouse models (time point dependent)	Not reported	Not reported in TMEV/spleen atrophy in cuprizone models	Mouse models—TMEV and cuprizone	Not reported
Additional demyelinating diseases	Patients: PML, Krabbe disease, Dogs: canine distemper virus	Not reported	Not reported	Dogs: canine distemper virus	Not reported
Traumatic Brain Injury	Patients	Not reported	Mouse models have immune cell loss from spleen	Mouse and rat models	Depressed homeostasis in the bone marrow
Spinal Cord Injury	Patients Mouse models	Not reported	Mouse models	Not reported	Not reported
Epilepsy	Patients Mouse models	Not reported	Mouse models	Mouse models	Not reported
Parkinson’s disease	Patients	Not reported	Not reported	Not reported	Not reported
CA/CPR	Patients Mouse models	Not reported	Mouse models	Mouse models	Not reported
BBB disruption	Patients Mouse models	Not reported	Not reported	Not reported	Not reported