. 2023 May 3;14:1176450. doi: 10.3389/fimmu.2023.1176450

Table 2.

mTEC subpopulations mirroring extra-thymic cell types identified by single-cell analysis.

Subset	Organism	Gene signature	Other description	Reference
Post-Aire mTEC	Mouse	Spink5, Ivl, Krt10, Krt80, Pigr, Ly6d, Cnfn, Flg	mTEC-III, Keratinocyte mTEC, Corneocyte-like mTEC, Spink5⁺ cell	(56, 59–69)
Post-Aire mTEC	Human	KRT1, KRT10, IVL		(56, 59–69)
Thymic tuft cell	Mouse	Pou2f3, Dclk1, Avil, Lrmp, Trpm5, Il25, Gng13, L1cam, Sox9, Chat	mTEC-IV, Tuft-like mTEC	(56, 59–69)
Thymic tuft cell	Human	POU2F3, DCLK1, GNAT3, GNB3, PLCB2, OVOL3	mTEC-IV, Tuft-like mTEC	(56, 59–69)
Microfold mTEC	Mouse	Sox8, Spib, Gp2, Ccl6, Ccl9, Ccl20, Ccr5, Tnfaip2, Tnfrsf11b	Gp2-preffered mTEC, Gp2⁺ TEC, Ccl6⁺ cell	(59, 65, 66, 68)
Neuroendocrine/ Secretory cell	Mouse	Snap25, Stxbp5l, Car8, Cd177	Structural TEC, TEC (neuro)	(60, 61, 63, 66, 68)
Neuroendocrine/ Secretory cell	Human	NEUROD1, NEUROG1, CHGA, BEX1	Structural TEC, TEC (neuro)	(60, 61, 63, 66, 68)
Ciliated cell	Mouse	Dynlrb2, Dnah12, Spag16, Wdr34, Bbs7, Tppp3, Fam183b	Cilia-TEC	(59, 63, 66, 68)
Ciliated cell	Human	ATOH1, GFI1, LHX3, FOXJ1	Cilia-TEC	(59, 63, 66, 68)
Myoid cell	Mouse	Myog, Myl1, Actc1	Muscle mTEC, TEC (myo)	(60, 63, 68)
Myoid cell	Human	MYOD1, MYOG, DES	Muscle mTEC, TEC (myo)	(60, 63, 68)
Lung mTEC	Mouse	Aqp4, Aqp5, Muc5b, Slc12a2, Bpifa1	Bpifa1⁺ cell	(65, 68)
Ionocyte	Mouse	Slc12a2, Atp6v1b1		(63, 68)
Ionocyte	Human	CFTR, FOXI1, ASCL3, CLCNKB		(63, 68)
Enterocyte/ Hepatocyte mTEC	Mouse	Reg3g, Saa1, Saa3, Aldob		(68)
Myelin⁺ cell	Human	SOX10, MPZ, MBP, S100A1		(63)