Figure 6.

Decreased multiunit activity (MUA) in medullary raphe and reduced breathing during a seizure. A) Seizure induced by 2 s stimulation of hippocampus (HC). After the stimulus, fast polyspike activity is seen in the HC local field potential (LFP). MUA from the medullary raphe shows marked suppression of neuronal firing during the seizure with slow recovery in the post-ictal period. Respiratory trace shows airflow amplitude (proportional to volume) and respiratory rate both decreased markedly during the ictal and post-ictal periods. B) Expanded segments of data from baseline, seizure, post-ictal, and recovery periods from the boxed regions in (A). Reproduced from Zhan et al (2016).