Fig 2. Simvastatin is identified by gene network-based predictions as the most likely drug in its category to reverse COVID-19 transcriptional profiles.

(a) Statins are predicted to shift the COVID-19 state to a healthy state, with simvastatin predicted for all datasets analyzed (14). Rosuvastatin was the only statin not predicted (n.p.) for any COVID-19 transcriptomics signatures. (b) 8 of 9 statins in the LINCS database were in the top 25% of drugs predicted for at least one dataset investigated. (c) Frequency of prediction for each statin when input datasets are stratified by sample source and tissue origin. Prediction frequency is normalized by the number of input datasets from each sample source and tissue origin.