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. 2023 May 5;19(5):e1011050. doi: 10.1371/journal.pcbi.1011050

Fig 4. Comparison of LINCS drug-gene interaction probability data for each statin.

Fig 4

(a) PCA plots of drug-gene interaction data for each statin reveals clustering of simvastatin, atorvastatin, and lovastatin when assessed across all genes in this dataset. (b) Distribution of LINCS drug-gene probabilities for statins that reduce mortality in patients. (c) Simvastatin, atorvastatin, and rosuvastatin share top gene targets (> 90th percentile), with the most shared between atorvastatin and simvastatin.