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. 2023 Mar 27;169(3):001307. doi: 10.1099/mic.0.001307

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© 2023 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.

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Fig. 10. — (a) Close-up of the interaction realized between OprM and MexA during MD simulations. A single OprM monomer (red ribbons) was reported to interact with three MexA protomers (green, yellow and purple ribbons). (b) Potential of mean force (PMF) for the translocation of rifampicin through the channel formed by MexA and OprM. The total cumulative energy suggests the process is diffusive as values range within thermal fluctuations. (c) Cross-section of the equilibrated fully assembled pump, showing the averaged volume of the conduit along the OprM and MexA complex encountered by the rifampicin drug during its translocation. Adapted with permission from [160].