Fig. 9.

Inhibitor binding sites (a) and major contributing residues (b) in AcrA. Sites I–III are predicted for NSC60339, clorobiocin and novobiocin, and additional sites predicted by FTMap (sites IV–VI). Sites I, II and III are located between the α-hairpin and lypoil domains, in the β-barrel domain, and between the β-barrel and MP domain, respectively. Site IV is located between the β-barrel and lypoil domain, and sites V and VI are in the MP domain. Adapted with permission from [152].