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. 2023 Apr 10;30(5):594–599. doi: 10.1038/s41594-023-00947-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Cryo-EM reconstruction of the Noc1–Noc2 RNP, visualizing domains I and II of the 25S rRNA with ITS2 and the 5.8S rRNA, and associated assembly factors and ribosomal proteins. b, Corresponding atomic model of the Noc1–Noc2 RNP, rotated by 180°. c, rRNA secondary structure diagram of the yeast LSU rRNA visualized in the Noc1–Noc2 RNP cryo-EM reconstruction. rRNA elements present in the structure are color-coded. Disordered segments are colored in white, and remodeled segments are indicated by dashed lines, with relevant helices numbered in black. d, The Noc1–Noc2 dimer clamps around root helix 2 of the pre-rRNA that is formed by base-pairing of the 5.8S and 25S rRNAs, and remodels root helices 25 and 26.