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. 2023 May 1;30(5):692–702. doi: 10.1038/s41594-023-00981-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, Schematic showing Taf1 binding at the +1 nucleosome in the GAL10 promoter region. b, Taf1 depletion and simultaneous RSC and Taf1 depletion increased the induction time of GAL10. Significance determined by two-sided bootstrap hypothesis testing⁵³; ****, P < 0.00005. P values: ±RSC, P < 10⁻¹⁵; ±Taf1, P < 10⁻¹⁵; ±RSC and Taf1, P < 10⁻¹⁵. c, Taf1 and RSC depletion had a smaller effect on induction time than expected based on the individual depletions, indicating that RSC and Taf1 have opposing functions. Gray bar, expected effect based on dynamic epistasis analysis. d, Taf1 and RSC depletion had the expected effect on time between consecutive bursts. Gray bar, expected effect based on dynamic epistasis analysis. Data in c and d are presented as the fractional change based on mean values ± s.d. based on 1,000 bootstrap repeats.

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