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. 2023 May 1;30(5):692–702. doi: 10.1038/s41594-023-00981-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, b MNase-seq analysis of (a) stable and (b) fragile nucleosomes in the GAL10 promoter region in active (galactose) and inactive (raffinose) conditions. c Schematic representation of nucleosome remodeling during activation of GAL10. Grey box: region with nucleosomes important for regulation of GAL10 that are discussed in this study. d, f, h, j, l, n Metagene MNase-seq analysis of stable or fragile nucleosomes (as indicated in the figure) upon RSC depletion by anchor-away of Sth1, SWI/SNF depletion by anchor-away of Swi2, or simultaneous depletion of RSC and SWI/SNF, averaged over all genes as annotated by⁶³, aligned at the location of the +1 nucleosome (black dashed line). e, g, i, k, m, o Heatmap of the log2-fold-change of depleted/nondepleted in nucleosome coverage of stable or fragile nucleosomes (as indicated in the figure) at all genes as annotated by⁶³, sorted by NDR width and aligned at the location of the +1 nucleosome, upon depletion of RSC, SWI/SNF or RSC and SWI/SNF depletion. Shown is one representative replicate out of two experiments for all except (j) and (k), which is a single replicate experiment.

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