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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Arthritis Rheumatol. 2023 Mar 10;75(5):794–805. doi: 10.1002/art.42413

Figure 2. A. Serum quantitative proteome of a panel of acute phase reactants in the proband.

Figure 2.

A. Relative protein abundances were measured by quantitative multiplexed proteomics. Bars represent mean protein relative abundance between replicates (if protein detected in both replicates). Error bars represent SEM. Serum quantitative proteomics showed multiple acute phase reactants increased in the proband, with many also elevated in the proband’s father (who also bore the NLRP3 V198M variant), and some increased in the proband’s mother. Non-gout healthy controls (n=3); controls with “common gout” n=3, none with palpable tophi. B. Key results for whole blood RNA-seq in proband compared to 3 healthy non-gout controls (using prior depletion of globin RNA, with 2 replicates for each sample). Data analysis shown is detailed further in the Supplementary Materials. STRING application-Protein Query generated a node network enriched in differentially expressed genes (DEGs), further separated into 8 clusters. Reactome Pathway queries identified functional pathways in each cluster.