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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Arthritis Rheumatol. 2023 Mar 10;75(5):794–805. doi: 10.1002/art.42413

Figure 6. intra-articular modulation of XO in synovium-resident macrophages (SRMs), and model for the lubricin and IL-1β circuit regulating gouty arthritis incidence and progression.

Figure 6.

A. Intra-articular IL-1β (10 ng) injection induced XO in (SRMs) knees of 2–3 months old Prg4GT/GT mice (n=6) and Prg4GTR/GTR mice (n=4). Prg4 reconstitution via recombination of Prg4GTR mice was done, with all mice receiving intraperitoneal tamoxifen at 3 weeks of age. Flow cytometry results for M1 and M2 SRMs and XO+ M1 and XO+ M2. 2-way ANOVA with Tukey’s pairwise comparisons. ns: non-significant; *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001. B. Model for dysfunction of a lubricin and IL-1β regulatory circuit that promotes gout development and progression independent of hyperuricemia, derived from collective results.