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. 2023 May 18;7(4):100182. doi: 10.1016/j.rpth.2023.100182

Figure 2.

Figure 2

Distribution of von Willebrand factor (VWF) in the lung (immunoperoxidase staining, 200×; inset and D, 400×). (A) Physiologic pattern in control lung tissue with positivity confined to the endothelial lining. (B) VWF in non–COVID-19 diffuse alveolar damage seen outside of the endothelium in the hyaline membranes and desquamated mononuclear cells as well as accentuated within vascular endothelial cells (insert). COVID-19: (C) COVID-19 diffuse alveolar damage with massive presence of VWF in the hyaline membranes, desquamated mononuclear cells, and a NETosis thrombus in the middle of the slide; (D) large VWF+ thrombus in a medium-sized vessel; (E) NETosis thrombi in small (also insert) and medium-sized pulmonary vessels enriched for VWF; (F) double staining for VWF and CD42b showing a large NETosis thrombus rich for VWF (red) with entrapped platelets (brown).