Table 1.
Baseline Donor, Recipient, and Lung Transplant Characteristics between Direct Recovery vs Thoracoabdominal Normothermic Regional Perfusion (TA-NRP) Donation After Circulatory Death (DCD) Transplants in the United States. Significant Values (p < 0.05) are Bolded
| Variable, n (%) | Direct recovery (n = 417) |
TA-NRP (n = 17) |
p-value |
|---|---|---|---|
| Donor characteristics | |||
| Age (years), median (IQR) | 40 (29-49) | 28 (21-36) | 0.003 |
| Male sex | 247 (59.2%) | 16 (94.1%) | 0.004 |
| Race/Ethnicity | 0.24 | ||
| White | 298 (71.5%) | 12 (70.6%) | |
| Black | 47 (11.3%) | 0 (0.0%) | |
| Hispanic | 61 (14.6%) | 5 (29.4%) | |
| Other | 11 (2.6%) | 0 (0.0%) | |
| Cause of death | 0.44 | ||
| Anoxia | 163 (39.1%) | 9 (52.9%) | |
| Cerebrovascular/Stroke | 119 (28.5%) | 2 (11.8%) | |
| Head trauma | 126 (30.2%) | 6 (35.3%) | |
| Other | 9 (2.2%) | 0 (0.0%) | |
| Abnormal chest x-ray | 289 (69.3%) | 13 (76.5%) | 0.53 |
| ≥20 pack year smoking history | 29 (7.0%) | 0 (0.0%) | 0.62 |
| Pa02/Fi02 ratio <300 | 40 (9.6%) | 0 (0.0%) | 0.39 |
| Ex vivo lung perfusion | 86 (20.6%) | 1 (5.9%) | 0.21 |
| Recipient characteristics | |||
| Age (years), median (IQR) | 62 (54-67) | 62 (58-64) | 0.86 |
| Male sex | 248 (59.5%) | 14 (82.4%) | 0.059 |
| Ethnicity | 0.88 | ||
| White | 323 (77.5%) | 14 (82.4%) | |
| Black | 46 (11.0%) | 1 (5.9%) | |
| Hispanic | 37 (8.9%) | 2 (11.8%) | |
| Other | 11 (2.6%) | 0 (0.0%) | |
| Diagnosis | 0.32 | ||
| Obstructive disease | 120 (28.8%) | 6 (35.3%) | |
| Pulmonary vascular disease | 12 (2.9%) | 0 (0.0%) | |
| Cystic fibrosis | 8 (1.9%) | 0 (0.0%) | |
| Restrictive disease | 264 (63.3%) | 9 (52.9%) | |
| Other | 13 (3.1%) | 2 (11.8%) | |
| Lung allocation score, median (IQR) | 38.7 (34.6-50.4) | 37.9 (34.2-39.3) | 0.27 |
| Total days on waitlist, median (IQR) | 31 (10-119) | 42 (12-76) | 0.90 |
| Transplant characteristics | |||
| Ischemic time (hours), median (IQR) | 7.1 (5.7-9.7) | 5.1 (4.4-6.0) | <0.001 |
| Donor to recipient hospital distance (miles), median (IQR) | 179 (76-359) | 142 (9-331) | 0.40 |
| Withdrawal of life support to asystole time (min), median (IQR) | 20 (15-26) | 23.5 (16-31) | 0.20 |
| Agonal time (min), median (IQR) | 16 (11-22) | 17.5 (14-25) | 0.35 |
| Asystole to clamp time (min), median (IQR) | 7 (4-9) | 100 (72-117) | <0.001 |
Abbreviations: TA-NRP, thoracoabdominal normothermic regional perfusion; IQR, interquartile range. Agonal time defined as time between systolic blood pressure <80 mm Hg or 02 saturation <80% and asystole.
Continuous variables were compared using Wilcoxon rank sum testing and expressed as median (interquartile range). Categorial variables were compared using Chi-square testing and expressed as number (percent).