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. Author manuscript; available in PMC: 2023 Nov 15.
Published in final edited form as: Cancer Res. 2023 May 15;83(10):1684–1698. doi: 10.1158/0008-5472.CAN-22-2433

Figure 2. Heterogenous response to LSD1 inhibition in LuCaP 96CR model.

Figure 2.

(A) Single-cell RNA-seq analysis demonstrated by the Uniform Manifold Approximation and Projection (UMAP) plot was generated (blue: vehicle, red: LSD1-i). (B) Expression levels of indicated genes were plotted onto the UMAP. (C) Cluster 1 (Vehicle treated) and cluster 3 (GSK treated) are highlighted. (D) Top-ranked genes that are differentially expressed between cluster 3 and cluster 1. (E) The GSEA showing the hallmark pathways that were significantly changed by GSK treatment (cutoff: P-adj<0.05). (F) The violin plot of MYC gene expression in Vehicle (cluster 1) vs. GSK2879552 (cluster 3).