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Enhancing photothermal efficiency. (A) By optimizing the spacing of a phototherapeutic agent within a nanoparticle matrix, it is possible to minimize both photobleaching and aggregation-induced quenching. Adapted with permission.[60] Copyright 2022, Wiley-VCH. (B) The hypoxia-tolerant TP-IS1 photosensitizer is loaded into M1 macrophages to enrich its tumor accumulation and elicit potent antitumor efficacy. Adapted with permission.[81] Copyright 2022, Wiley-VCH.
