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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Small Methods. 2023 Mar 24;7(5):e2300252. doi: 10.1002/smtd.202300252

Figure 5.

Figure 5.

Improving tumor accumulation. (A) Semiconducting polymer nanoparticles are conjugated with the protease bromelain, which can be activated under laser irradiation to degrade collagen and enhance tumor penetration. Adapted with permission.[131] Copyright 2018, Wiley-VCH. (B) Laser-triggered drug release is realized by incorporating the lipophilic photosensitizer 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR) into RBC membrane, which is coated around self-assembled nanoparticles comprised of heparan sulfate (HS) conjugated to either docetaxel (DTX, HD) or calcitriol (CTL, HC). Adapted with permission.[144] Copyright 2022, Wiley-VCH.