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. 2023 May 17;13:8002. doi: 10.1038/s41598-023-35098-4

Figure 4.

Figure 4

The protective role of sRAGE in relation to rheumatoid arthritis. Depiction of the protective mechanism of sRAGE in relation to RA. RAGE is a membrane-bound receptor that triggers pro-inflammatory pathways implicated with RA. sRAGE, a circulating form of RAGE, acts as a decoy receptor for RAGE ligands and therefore downregulates pro-inflammatory pathways.