Table 2.
Mendelian randomization external replication for sRAGE in relation to rheumatoid arthritis and rheumatoid factor.
| A. | |||||
|---|---|---|---|---|---|
| Exposure | Outcome | nsnp/SNP | Effect size | 95% CI | P value |
| FHS pQTL for sRAGE* | MRCIEU RA GWAS* | 3 | 0.364 | [0.342; 0.385] | 6.40E−241 |
| rs2070600 | 0.475 | [0.446; 0.505] | 5.25E−122 | ||
| rs9266529 | 1.365 | [0.829; 2.249] | 0.222 | ||
| rs6923504 | 0.004 | [0.003; 0.005] | < E308 | ||
| UK Biobank RA GWAS | 3 | 0.420 | [0.191; 0.924] | 0.031 | |
| rs2070600 | 0.475 | [0.419; 0.539] | 1.03E−30 | ||
| rs9266529 | 0.607 | [0.431; 0.854] | 0.004 | ||
| rs6923504 | 0.053 | [0.034; 0.081] | 8.77E−40 | ||
| INTERVAL pQTL for sRAGE | MRCIEU RA GWAS* | 1 | 0.394 | [0.317; 0.472] | 5.25E−122 |
| rs2070600 | |||||
| UK Biobank RA GWAS | 1 | 0.395 | [0.236; 0.553] | 1.03E−30 | |
| rs2070600 | |||||
| B. | |||||
|---|---|---|---|---|---|
| Exposure | Outcome | nsnp/SNP | Effect size | SE | P value |
| FHS pQTL for sRAGE* | UK Biobank RF GWAS* | 3 | − 1.318 | 0.43 | 0.002 |
| rs2070600 | − 1.262 | 0.48 | 0.008 | ||
| rs9266529 | − 1.877 | 1.35 | 0.164 | ||
| rs9266529 | − 1.150 | 1.62 | 0.478 | ||
| INTERVAL 1 pQTL for sRAGE | UK Biobank RF GWAS* | 1 | − 1.58 | 0.60 | 0.008 |
| rs2070600 | |||||
Effect size for RA is odds ratio per 1 standard deviation [SD] increment in inverse rank-normalized sRAGE levels.
Effect size for RF is the change in RF level per 1 standard deviation [SD] increment in inverse rank-normalized sRAGE levels.
* = dataset used for primary analysis.