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. 2023 May 17;13:8026. doi: 10.1038/s41598-023-34772-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Genes differentially expressed in Tfap2b^−/− developing mouse brains. We compared gene expression between homozygous mutant embryos (E14.5) and their wild-type littermates. Volcano plots showing the significantly up-regulated (red) and down-regulated genes (blue) in female SP (A) and DMH (B). Up regulated genes are presented in orange for male (C) and DMH (D). We compared gene expression between homozygous mutant embryos (E14.5) and their wild-type littermates. Significantly changed genes as defined by an FDR (False Discovery Rate) < 0.2 and a logFC > 0.5 were highlighted and the most robustly regulated genes were labeled (FDR < 0.01; logFC > 2). Female E14.5 embryos tfap2b^+/+, n = 3; female E14.5 embryos tfap2b^−/−, n = 2 (based on PCA analysis shown in Fig. S1, the sample named “mut3” was excluded from the DE genes analysis); male E14.5 embryos tfap2b^+/+, n = 3; male E14.5 embryos tfap2b, n = 3; SP, secondary prosencephalon; DMH, diencephalon, midbrain and hindbrain.