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. 2023 May 17;14:2819. doi: 10.1038/s41467-023-38392-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Fluorescence signals derived from Reverbα-Venus-NLS-PEST reporter at single-cellular level are shown. The black line is averaged fluorescence signal, indicating the population rhythms. A stimulus of 2 μM forskolin was applied to cells 108 h after the beginning of the measurement. b PRCs for forskolin treatment at different concentrations at single-cellular level. c SRs to forskolin at different concentrations. Fluorescence rhythms of all individual cells were averaged and then normalized. The dotted line indicates the treatment of forskolin. d Amplitude parameter R′ in SRs and PRCs. “UT” represents untreated condition. e Phase parameter Θ′ in SRs and PRCs. f SRs to indicated resetting agents. Fluorescence rhythms of all individual cells were averaged and then normalized. The dotted lines indicate the treatments. g Amplitude of PRCs and SRs for different concentrations of agents. The linear black line is the regression line for calibration parameter β in Eq. (7). R² is the coefficient of determination. FK means forskolin. h Phase of PRCs and SRs for different concentrations of agents. The linear black line indicates the line of y = x.