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Wild-type, Gpr43−/− and Gpr109A−/− mice developed equivalent degrees of hyperglycaemia. STZ induced diabetes in WT, GPR43−/− and GPR109A−/− mice of similar severity, as indicated by blood glucose (A) and body weight (B) profiles over a 12-week period. n = 8–12 in diabetic groups. Age matched non-diabetic controls n = 5 mice per group. Data are shown as means ± SD.
