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SCFA reduce glomerular and interstitial injury in DN through GPR43. Acetate was ineffective in ameliorating diabetic nephropathy in GPR43−/− diabetic mice, with no reduction in kidney to body weight ratio (A), glomerular volume (B), glomerular hyper-cellularity (C) or interstitial fibrosis (D) at 12 weeks compared to WT diabetic controls. (E, F) Representative sections of kidney from WT and GPR43−/− mice at 12 weeks (PAS and PSR stained, ×400 magnification).
