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. 2023 May 4;11:1182570. doi: 10.3389/fcell.2023.1182570

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Copyright © 2023 Li, Ma, Loh, Chadban and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Butyrate reduces diabetic glomerular injury through GPR109A. Butyrate treatment in GPR109A−/− diabetic mice did not alter kidney to body weight ratio (A) but resulted in less glomerular hypertrophy (B) and glomerular hypercellularity (C) compared to WT diabetic controls. Increased interstitial collagen deposition was partially attenuated by butyrate treatment in GPR109A−/− diabetic mice (D, F). (E, F) Representative sections of kidney from WT and GPR109A−/− mice at 12 weeks (PAS and PSR stained, ×400 magnification).