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. 2023 May 4;14:1114770. doi: 10.3389/fimmu.2023.1114770

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Copyright © 2023 Hussein, Li, Mao, Peng and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TCR-JUN T cells are more functional inside solid tumor lesions. (A) The gating strategy of the single cell suspensions from treated tumors. (B, C) ICS of the IL2 and IFNγ in the tumor infiltrating TCR+ T cells from the TCR-T and TCR-JUN T treated tumors (5 tumors in each group). Data represent mean ± SEM. (D) Killing assay of tumor infiltrating TCR+ T cells isolated 13 days after treatment with TCR or TCR-JUN T cells. Each point represents the mean ± SD of three repeating wells (15 pictures).