Table 3.
Comparison of MOG-specific CD8+ T cells and memory T cell subsets in peripheral blood between patients with multiple sclerosis (MS), other neurological disease (OND) and healthy controls (HC).
| Total CD8+ (%) | Naïve (%) | TCM (%) | TEM (%) | TEMRA (%) | |
|---|---|---|---|---|---|
| MS (n=24) | 0.21 (0.12,0.37) **∆∆ | 16.7(5.46,35.30)*∆ | 11.95 (9.38,13.88) **∆∆ | 37.0 (25.33,44.98) **∆∆ | 0.25 (0,4.22) **∆∆ |
| OND (n=23) | 0.09 (0.03,0.11) | 32.40(25.0,46.60) | 3.14 (1.63,4.81) | 12.30 (7.60, 28.60) | 0 (0,0) |
| HC (n=24) | 0.04 (0,0.1) | 30.15(21.18,48.35) | 4.65 (3.40,7.65) | 10.90 (4.48,21.38) | 0 (0,0) |
| P value | <0.0001 | 0.0184 | <0.0001 | <0.0001 | 0.0018 |
Data are median with range. **p < 0.01 or *p < 0.05 for post hoc comparison with HC; ∆∆p < 0.01 or ∆p < 0.05 for post hoc comparison with OND group. TCM, central memory T cells; TEM, effector memory T cells; TEMRA, terminally differentiated cells.