Fig. 6.

Combinatorial treatments enhance cytotoxicity. (A) Cytotoxicity assay of T and iNKT cells (both previously exposed to inhibitors for 24h) against MLLr target cells. Experiments were performed in n=4 biological replicates. (B) Cytotoxicity assay of T and iNKT cells (both previously exposed to inhibitors for 24h) against MLLr target cells (previously exposed to inhibitors for 48h); PD-1 (C) and PD-L1 (D) expression on effector and target cells was analyzed simultaneously. Experiments were performed in n=5 (T cells) and n=3 (iNKT cells) biological replicates. Inhibitor concentrations: 100 nM JQ-1, 10 µM MAT2Ai, 1 µM PRMT5i. Statistical analysis with One-Sample t test, *p < 0.05.