Figure 2.

Photoreceptor layer thickness is preserved with expression of NMNAT1 in the neural retina

Measurements of retinal thickness measured from the outer plexiform layer (OPL) to the retinal pigment epithelium (RPE). Measurements are based on SD-OCT imaging of retinas from mice treated with scAAV9 with promoters driving expression of hNMNAT1 in various cell types. The promoters used include (A) CASI (most cell types), (B) hGRK1 (rods and some RPE), (C) ProC1 (photoreceptors), (D) VMD2 (RPE), (E) ProC3 (ganglion cells), (F) ProD5 (rods). GCL, ganglion cell layer; INL, inner nuclear layer; SD-OCT, spectral-domain optical coherence tomography. Statistically significant preservation of retinal thickness between treated and untreated Nmnat1^V9M/V9M retinas are noted by red asterisks (n $\ge$ 3 WT and n $\ge$ 5 Nmnat1^V9M/V9M mice for each promoter at each age, two-way ANOVA, multiple comparisons, p < 0.05, error bars represent the SEM, points represent the respective retinal thickness for each eye from a single mouse).