Table 2.
Frequency of C3435T and G2677T genotypes and allelic polymorphisms in KTRs (AR, non-AR groups) and controls
| All KTRs (n = 83) | AR group (n = 36) |
None AR group (n = 47) | Controls (n = 80) | AR vs. None AR | AR vs. Controls | None AR vs. Controls | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | N (%) | N (%) | N (%) | OR (95% CI) |
P value | OR (95% CI) |
P value | OR (95% CI) |
P value | |||
| C3435T | Genotype | TT | 22 (26.5) | 3 (8.3) | 19 (40.4) | 24 (30) | Reference | - | Reference | - | Reference | - |
| CT | 35 (42.2) | 20 (55.6) | 15 (31.9) | 40 (50) |
3.58 (1.64–7.80) |
0.001 |
2.20 (1.08–4.46) |
0.028 |
0.63 (0.37–1.06) |
0.082 | ||
| CC | 26 (31.3) | 13 (36.1) | 13 (27.7) | 16 (20) |
2.99 (1.32–6.75) |
0.008 |
2.98 (91.37–6.46) |
0.006 |
1.02 (0.56–1.83) |
0.957 | ||
| Allele | T | 79 (47.6) | 26 (36.1) | 53 (56.4) | 88 (55) | Reference | - | Reference | - | Reference | - | |
| C | 87 (52.4) | 46 (63.9) | 41 (43.6) | 72(45) |
1.67 (1.13–2.46) |
0.010 |
1.59 (1.13–2.24) |
0.008 |
0.97 (0.70–1.32) |
0.83 | ||
| G2677T | Genotype | GG | 23 (27.7 | 5 (13.9) | 18 (38.3) | 39 (48.8) | Reference | - | Reference | - | Reference | - |
| GT | 37 (44.6 | 19 (52.8) | 18 (38.3) | 28 (35) | 2.259 (1.12–4.555) | 0.023 | 2.625 (1.43–4.817) | 0.002 | 1.226 (0.743–2.021) | 0.425 | ||
| TT | 23 (27.7) | 12 (33.3) | 11 (23.4) | 13 (16.3) | 2.306 (1.069–4.975) | 0.033 | 3.181 (1.592–6.356) | 0.001 | 1.455 (0.793–2.668) | 0.226 | ||
| Allele | G | 83 (50) | 29 (40.3) | 54 (57.4) | 106 (66.3) | Reference | - | Reference | - | Reference | - | |
| T | 83 (50) | 43 (59.7) | 40 (42.6) | 54 (33.8) | 1.541 (1.047–2.268) | 0.028 | 1.91 (1.353–2.697) | < 0.001 | 1.261 (0.911–1.744) | 0.162 | ||
KTR; kidney transplant recipients, N; number, OR; odds ratio, CI; confidence interval, C; cytosine, T; thymine, G; guanine. Logistic regression analysis was used. AR; acute rejection; N; number, OR; odds ratio, CI; confidence interval, C; cytosine, T; thymine. Logistic regression analysis was used. Reference genotype and allele according to NCBI. P < 0.05 is considered significant; OR < 1 is considered protective; OR > 1 is considered risky