Table 4.
Comparison of tacrolimus doses and trough levels according to the C3435T and G2677T genotypes
| C3435T genotypes | G2677T genotypes | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables | CC (n = 26) | CT (n = 35) | TT (n = 22) | P value | GG (n = 23) | GT (n = 37) | TT (n = 23) | P value |
| Median (IQR) | Median (IQR) | |||||||
| Trough level (ng/ml) | ||||||||
| 1st month | 7.9 (5.8-9) | 7.3 (6-9.5) | 7.8 (7-9.3) | 0.9 | 7.6 (4.3–9.9) | 7.9 (2.5-8) | 7.6 (2.5–8.3) | 0.896 |
| 2nd month | 8 (6.3–9.4) | 9.8 (7.2–10) | 9.8 (7–11) | 0.7 | 9.9 (5.2–10.3) | 9.5 (5.2–10.3) | 9.7 (6–10) | 0.530 |
| 3rd month | 8 (6.7–9.6) | 8.5 (6.7–10.2) | 9.2 (8.5–10.5) | 0.083 | 9.2 (4.5–9.5) | 9 (4.5–10) | 7.5 (4.5-9) | 0.012 |
| 4th month | 7.2 (6-9.7) | 9.3 (7.2–10.3) | 9 (8–10) | 0.2 | 9.3 (4.4–10) | 8.3 (4.2–9.6) | 7.7 (5.1–8.7) | 0.081 |
| 5th month | 7.4 (5–10) | 8.4 (5-10.2) | 8.2 (5-9.8) | 0.2 | 8.4 (5-9.5) | 8.3 (5-9.7) | 7 (5-8.4) | 0.135 |
| 6th month | 6.6 (6-8.5) | 7.4 (4.7–9.6) | 7 (4.7–9.1) | 0.1 | 7.4 (4.4-9) | 7.2 (2.5-8) | 6 (4.5–7.9) | 0.850 |
| Mean trough level of 1st 6 months (ng/ml) | 8 (5.9–9.3) | 8.5 (6.1–9.9) | 8.65 (6.7–9.95) | 0.154 | 9.18 (4.6–9.9) | 8.51 (6.43–9.5) | 7.98 (6.21–8.5) | 0.043 |
| TAC dose (mg/kg/day) | ||||||||
| 1st month | 0.3 (0.2–0.3) | 0.18 (0.15–0.2) | 0.16 (0.14–0.18) | < 0.001 | 0.17 (0.08–0.23) | 0.18 (0.1–0.26) | 0.27 (0.14–0.3) | < 0.001 |
| 2nd month | 0.27 (0.2–0.3) | 0.18 (0.15–0.19) | 0.18 (0.15–0.19) | < 0.001 | 0.17 (0.04–0.25) | 0.18 (0.13–0.26) | 0.26 (0.13–0.29) | < 0.001 |
| 3rd month | 0.28 (0.2–0.31) | 0.18 (0.15–0.2) | 0.15 (0.13–0.19) | < 0.001 | 0.15 (0.04–0.23) | 0.18 (0.11–0.25) | 0.28 (0.13–0.3) | < 0.001 |
| 4th month | 0.29 (0.18–0.3) | 0.16 (0.13–0.24) | 0.12 (0.08–0.16) | < 0.001 | 0.13 (0.04–0.21) | 0.16 (0.07–0.2) | 0.29 (0.12–0.3) | < 0.001 |
| 5th month | 0.24 (0.17–0.3) | 0.17 (0.13–0.19) | 0.1 (0.06–0.17) | < 0.001 | 0.14 (0.05–0.22) | 0.17 (0.06–0.21) | 0.23 (0.1–0.26) | < 0.001 |
| 6th month | 0.23 (0.18–0.3) | 0.17 (0.13–0.23) | 0.13 (0.08–0.15) | 0.001 | 0.13 (0.07–0.2) | 0.18 (0.04–0.22) | 0.23 (0.1–0.25) | 0.003 |
| Mean TAC dose (mg/kg/day) | 0.27 (0.2–0.32) | 0.17 (0.15–0.2) | 0.14 (0.12–0.19) | < 0.001 | 0.15 (0.055–0.22) | 0.17 (0.115–0.23) | 0.27 (0.12–0.28) | < 0.001 |
| C/D ratio (ng/ml/mg/kg/day) | ||||||||
| 1st month | 25 (17.6–51.2) | 49.5 (31.1–64.6) | 54.3 (38.1–66.7) | 0.002 | 51.18 (23.33–100.5) | 40 (8.33–62.86) | 35 (8.33–62.5) | 0.024 |
| 2nd month | 25.5 (23.8–50) | 55.6 (43.9–72) | 55 (35.6–71.4) | < 0.001 | 64.71 (18.67-80) | 50 (20.83–77.22) | 25.53 (9.43–79.23) | 0.001 |
| 3rd month | 26.9 (21.4–37.2) | 45 (32.5–90) | 65.4 (50.7-105.6) | < 0.001 | 65.38 (29.63-90) | 40.63 (14.43–66.3) | 26.92 (14.43–57.4) | < 0.001 |
| 4th month | 27.1 (20.7–42.5) | 49 (38-66.3) | 72.7 (54.7–150) | < 0.001 | 66.25 (20.38–70.5) | 42.86 (8.95–67.5) | 27.08 (8.95–47.67) | < 0.001 |
| 5th month | 30.4 (21.8–41) | 41.2 (33.3–78.8) | 69.2 (57.9-101.7) | < 0.001 | 60 (28-96.67) | 41.18 (10.38–76.6) | 25.16 (10.38–65.4) | < 0.001 |
| 6th month | 30 (21.4–42.9) | 43 (30.7–58.8) | 58.8 (38.3–91) | 0.001 | 56.3 (28.7–86.9) | 42.9 (13.8–77.5) | 26.7 (13.1–60.6) | 0.002 |
| Mean C/D ratio in 1st six months | 30.2 (22.4–38.5) | 47.3 (38.5–74) | 68.1 (49.9-106.3) | < 0.001 | 68.1 (26.6–90) | 47.3 (13–83) | 29.2 (13-75.2) | < 0.001 |
N; number, IQR; inter quartile range, TAC; tacrolimus, C; cytosine, T; thymine, G; guanine, ng/ml; nanogram per milliliter, C/D; trough concentration/dose, Kruskal Wallis test was used for comparison