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. 2008 Jul 22;6(7):766. doi: 10.2903/j.efsa.2008.766

Selenium‐enriched yeast as source for selenium added for nutritional purposes in foods for particular nutritional uses and foods (including food supplements) for the general population ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food

European Food Safety Authority (EFSA)
PMCID: PMC10193646  PMID: 37213858

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Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission on Selenium‐enriched yeast as source for selenium. The EFSA Journal (2008) 766, 1–43.

Panel members: F. Aguilar, H. Autrup, S. Barlow, L. Castle, R. Crebelli, W. Dekant, K.‐H. Engel, N. Gontard, D. Gott, S. Grilli, R. Gürtler, J.‐C. Larsen, C. Leclercq, J.‐C. Leblanc, F. X. Malcata, W. Mennes, M.‐R. Milana, I. Pratt, I. Rietjens, P. Tobback, F. Toldrá.

Acknowledgement: The European Food Safety Authority wishes to thank the members of the Working Group for the preparation of this opinion: F. Aguilar, D. Boskou, D. Gott, S. Grilli, R. Guertler, K. Hulshof, J.C. Larsen, J.C. Leblanc, C. Leclercq, A. Mortensen, D. Parent‐Massin, I. Pratt, I. Rietjens, P. Tobback, G. Speijers, F. Toldra.

Adoption date: 9 July 2008

Published date: 22 July 2008

Question number: EFSA‐Q‐2005‐078, EFSA‐Q‐2005‐119, EFSA‐Q‐2005‐186, EFSA‐Q‐2006‐215, EFSA‐Q‐2006‐216, EFSA‐Q‐2006‐217

References

  1. Aaseth, J. , Haugen, M. , Forre, O. , 1998. Rheumatoid arthritis and metal compound perspectives on the role of oxygen radical detoxification. Analyst, January 123, 3–6. [DOI] [PubMed] [Google Scholar]
  2. Alfthan, G. , and Nève, J. , 1996. Selenium intakes and plasma selenium levels in various populations. In Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention, pp. 161–167 [Kumpulainen J. and Salonen J., editors]. Cambridge: Royal Society of Chemistry. [Google Scholar]
  3. Alfthan, G. , Ara, A. , Arvilommi, H. , Huttunen, J.H. , 1991. Selenium metabolism and platelet glutathione peroxidase activity in healthy Finnish men: effects of selenium yeast, selenite, and selenium. American Journal of Clinical Nutrition 53, 120–125. [DOI] [PubMed] [Google Scholar]
  4. Anundi, I. , Ståhl, A. and Högberg, J. , 1984. Effects of selenite on O2 consumption, glutathione oxidation and NADPH levels in isolated hepatocytes and the role of redox changes in selenite toxicity. Chem Biol Interactions 50, 77–288. [DOI] [PubMed] [Google Scholar]
  5. Behne, D. , 2005. Selenium retention in the skeletal muscle of humans after long‐term supplementation with selenium enriched yeast and selenomethionine, and the relationship between the selenium concentrations in skeletal muscle and in the monitor materials hair, nails, blood, and blood fractions. Technical report to a petitioner.
  6. Becker, W. , 1989. Food Habits and Nutrient Intake in Sweden, 1989. Uppsala, Sweden: Swedish National Food Administration. [Google Scholar]
  7. Berry, M.J. Banu, L. , Yoyi Chen, Mandel, S.J. , Kieffer, J.D. , Harney, J.W. , Reed Larsan, P. , 1991. Recognition of UGA as a Selenocysteine codone in type 1 deiodinase, requires sequences in the 3′ untranslated region. Nature Vol. 353, 273–276. [DOI] [PubMed] [Google Scholar]
  8. Berry, M.J. 1993. Functional characterisation of the eukaryotic SECIS elements which direct Selenocysteine insertion at UGA codons. The EMB Journal Vol. 12, no. 8, 3315–3322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bogye, G. , Alfthan, G. , Machay, T. , 1998. Randomized clinical trial of enteral yeast‐selenium supplementation in preterm infants. Biofactors 8 (1–2), 139–142. [DOI] [PubMed] [Google Scholar]
  10. Brätter, P. , Negretti de Brätter, V.E. , Jaffe, W.G. , Mendez Castellano, H. , 1991a. Selenium status of children living in seleniferous areas of Venezuela. J Trace Elem. Electrolytes Health Dis. Vol. 5, 163–166. [PubMed] [Google Scholar]
  11. Brätter, P. , Negretti de Brätter, V.E. , Rösick, U. , von Stockhausen, H.B. , 1991b. Selenium in the nutrition of infants: influence of the maternal selenium status. Trace elements in the nutrition of children II (ed. Chandra R K). Nestlé Nutrition Workshop Series, Vol 23. [Google Scholar]
  12. Brätter, P. , Negretti de Brätter, V.E. , 1996. Influence of high dietary selenium intake on the thyroid hormone level in human serum. J Trace Elements Med. Biol. Vol 10, 163–166. [DOI] [PubMed] [Google Scholar]
  13. Bügel, S. , Larsen, E.H. , Sloth, J.J. , Flytlie, K. , Overvad, K. , Steenberg, L.C. , Moesgaard, S. , 2004. Selenium from a high selenium yeast supplement is well absorbed and retained in humans. In: Cser MA et al. (eds.) Metal Ions in Biology and Medicine, Vol 8, pp. 206–209. John Libbey & Company Ltd. London UK. [Google Scholar]
  14. Burk, R.F. , Norsworthy, B.K. , Hill, K.E. , Motley, A.K. , Byrne, D.W. , 2006. Effects of chemical form of selenium on plasma biomarkers in a high‐dose human supplementation trial. Cancer. Epidemiol. Biomarkers. Prev. 15 (4), 804–810. [DOI] [PubMed] [Google Scholar]
  15. Choy, W.N. , Willhite, C.C. , Cukierski, M.J. and Book, S.A. , 1989. Primate micronucleus study of L‐selenomethionine. Environ Mol Mutagen 14, 123–125. [DOI] [PubMed] [Google Scholar]
  16. Choy, W.N. , Henika, P.R. , Willhite, C.C. and Tarantal, A.F. , 1993. Incorporation of a micronucleus study into developmental toxicology and pharmacokinetic study in nonhuman primates. Environ Mol Mutagen 21, 73–80. [DOI] [PubMed] [Google Scholar]
  17. Clark, L.C. , Combs, G.F. , Turnbull, B.W. , Slate, E.H. , Chalker, D.K. , Chow, J. , Davis, L.S. , Glover, R.A. , Graham, G.F. , Gross, E.G. , Krongrad, A. , Lesher, J.L. , Park, H.K. , Sanders, B.B. , Smith, C.L. , Taylor, J.R. , 1996. Effects of selenium supplementation for cancer prevention in patents with carcinoma of the skin. Journal of the American Medical Association 276, 1957–1957. [PubMed] [Google Scholar]
  18. Clausen, J. , Nielsen, S.A. , 1988. Comparison of whole blood selenium values and erythrocyte glutathione peroxidase activities of normal individuals on supplementation with selenate, selenite, L‐selenomethionine and high selenium yeast. Biological Trace Element Research 15, 125–138. [DOI] [PubMed] [Google Scholar]
  19. Combs, G.F. Jr. , 2001. Selenium in global food systems. Br. J. Nutr. 85 (5), 517–547. [DOI] [PubMed] [Google Scholar]
  20. Combs, G.F. Jr. & Combs, S.B. , 1986. The biological availability of selenium in foods and feeds. In The Role of Selenium in Nutrition, pp. 127–177, New York, NY: Academic Press. [Google Scholar]
  21. Danskernes kostvaner, 1995. Danish Institute for Food and Veterinary Research unpublished results, cited in Rayman, 2004.
  22. Deagen, J.T. , Butler, J.A. , Beilstein, M.A. and Whanger, P.D. , 1987. Effects of dietary selenite, selenocystine and selenomethionine on selenocysteine lyase and glutathione peroxidase activities and on selenium levels in rat tissues. Journal of Nutrition 117, 91–98. [DOI] [PubMed] [Google Scholar]
  23. Djujic, I. , Djujic, B. and Trajkovic, L. , 1995. Dietary intake of selenium in Serbia: results for 1991. Naucni Skupovi (Srpska Akademija Nauka I Umetnosti). Odeljenje Prirodno‐Matematickih Nauka 6, 81–87. [Google Scholar]
  24. Dorea, J.G. , 2002. Selenium and breast feeding. British Journal of Nutrition 88, 443–461. [DOI] [PubMed] [Google Scholar]
  25. EFSA (European Food Safety Authority) , 2006a. Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product Sel‐Plex®2000 as a feed additive according to Regulation (EC) No 1831/2003 (Question No EFSA‐Q‐2005‐071).
  26. EFSA (European Food Safety Authority) , 2006b. Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product Selenium‐enriched yeast (Saccharomyces cerevisiae NCYC R397) as a feed additive for all species in accordance with Regulation (EC) No 1831/2003.
  27. EVM (Expert Group on Vitamins and Minerals) , 2003. Safe Upper Levels for Vitamins and Minerals: 232–239 and EVM/99/17P, 1–53.
  28. Fardy, J.J. , McOrist, G.D. and Farrar, Y.J. , 1989. The determination of selenium in the Australian diet using neutron activation analysis. J Radioanal Nucl Chem 133, 391–396. [Google Scholar]
  29. Ferm, V.H. , Hanlon, D.P. , Willhite, C.C. , Choy, W.N. and Book, S.A. , 1990. Embryotoxicity and dose‐response relationships of selenium in hamsters. Reprod Toxicol 4, 183–190. [DOI] [PubMed] [Google Scholar]
  30. Forsberg, L. , 1999. The effect of selenocystine, selenomethionine, and selenium yeast regarding status of selenium and glutathione peroxidase activity. MSc thesis, Copenhagen University, Denmark. [Google Scholar]
  31. FNB , 2000. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Food and Nutrition Board (FNB). National Academy Press, Washington, DC. [PubMed] [Google Scholar]
  32. Fox, T.E. , Van den Heuvel, E.G.H.M., Atherton, C.A. , Dainty, J.R. , Lewis, D.J. , Langford, N.J. , Crews, H.M. , Luten, J.B. , Lorentzen, M. , Sieling, F.W. , Van Aken‐Schnyder, P. , Fairweather‐Tait, S.J. , 2004. Bioavailability of selenium from fish, yeast and selenate: A comparative study in humans using stable isotopes. European Journal of Clinical Nutrition 58, 343–349. [DOI] [PubMed] [Google Scholar]
  33. Garberg, P. , Ståhl, A. , Warholm, M. and Högberg, J. , 1988. Studies on the role of DNA fragmentation in selenium toxicity. Biochem Pharmacol 37, 3401–3406. [DOI] [PubMed] [Google Scholar]
  34. Gissel‐Nielsen, G. , 1998. Effects of selenium supplementation of field crops. In Environmental Chemistry of Selenium, pp. 99–112 [Frankenberger Jr WT and Engberg RA, editors]. New York, NY: Marcel Dekker. [Google Scholar]
  35. Griffiths, J.C. , Matulka, R.A. , Power, R. , 2006. Genotoxicity studies on Sel‐Plex, a standardized, registered high‐selenium yeast. Int J Toxicol. 25, 477–85. [DOI] [PubMed] [Google Scholar]
  36. Griffiths, N.M. , Stewart, R.D. , Robinson, M.F. , 1976. The metabolism of [75Se] in four women. Br. J. Nutr. 35, 373–382. [DOI] [PubMed] [Google Scholar]
  37. Hawkes, W.C. , Willhite, C.C. , Craig, K.A. , Omaye, S.T. , Cox, D.N. , Choy, W.N. & Hendrickx, A.G. , 1992, Effects of excess selenomethionine on selenium status indicators in pregnant long‐tailed Macaques (Macaca fascicularis) . Biol. Trace Elem. Res. 35, 281–297. [DOI] [PubMed] [Google Scholar]
  38. Hercberg, S. , Galan, P. , Preziosi, P. , Bertrais, S. , Mennen, L. , Malvy, D. , Roussel, A‐M. , Favier, A. , Briancon, S. , 2004. The Su.Vi.Max study. A randomized, placebo‐controlled trial of the health effects of antioxidant vitamins and minerals. Arch. Inter. Med. 164, 2335–2342. [DOI] [PubMed] [Google Scholar]
  39. Institut Rosell , 2004. Sub‐acute toxicity of selenium yeast: a 28 day supplement study in rats. Report No. CR‐03SAAR‐B. KGK Synergize Inc., Ontario, Canada
  40. Kadrabová, A. J. , Madaric, A. and Ginter, E. , 1998. Determination of the daily selenium intake in Slovakia. Biological Trace Elements Research 61, 277–286. [DOI] [PubMed] [Google Scholar]
  41. Keshan Disease research group , 1979, Epidemiologic studies on the etiologic relationship of Selenium and Keshan Disease. Chinese Medical Journal 92 (7), 477–482. [PubMed] [Google Scholar]
  42. Kim, Y.Y. , Mahan, D.C. , 2001. Comparative effects of high dietary levels of organic and inorganic selenium on selenium toxicity of growing‐finishing pigs. Journal of Animal Science 79 (4), 942–948. [DOI] [PubMed] [Google Scholar]
  43. Klapec, T. , Mandic, M.L. , Grigic, J. , Primorac, L. , Ikic, M. , Lovric, T. , Grigic, Z. and Herceg, Z. , 1998. Daily dietary intake of selenium in eastern Croatia. Science of the Total Environment 217, 127–136. [DOI] [PubMed] [Google Scholar]
  44. Kotrebai, M. , Birringer, M. , Tyson, J.F. , Block, E. , and Uden, P.C. , 2000. Selenium speciation in enriched and natural samples by HPLC‐ICP‐MS and HPLC‐ESI‐MS with perfluorinated carboxylic acid ion‐pairing agents. Analyst 125, 71–78. [DOI] [PubMed] [Google Scholar]
  45. Kramer, G.F. and Ames, B.N. , 1988. Mechanisms of mutagenicity and toxicity of sodium selenite (Na2SeO3) in Salmonella typhimurium . Mutat Res 201, 169–180. [DOI] [PubMed] [Google Scholar]
  46. Kumpulainen, J. , Salmenperä, L. , Siimes, M.A. , Koivistoinen, P. , Perheentupa, J. , 1985. Selenium status of exclusively breast‐fed infants as influenced by maternal organic or inorganic selenium supplementation. American Journal of Clinical Nutrition 42, 829–835. [DOI] [PubMed] [Google Scholar]
  47. Kumpulainen, J.T. , 1993. Selenium in foods and diets of selected countries. J Trace Elem Electrolytes Health Dis 7, 107–108. [Google Scholar]
  48. Kvícala, J. , Zamrazil, V. and Jiranek, V. , 1996. Selenium deficient status of the inhabitants of South Moravia. In Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention, pp. 177–187 [Kumpulainen J. and Salonen J., editors]. Cambridge: Royal Society of Chemistry. [Google Scholar]
  49. Kvícala J., Zamrazil, V. , Nemecek, J. , Jiranek, V. , 2003. Influence of short‐term selenium supplementation of various quantities of organically bound selenium upon serum and urine selenium concentration. Trace Elements and Electrolytes 20 (2), 94–98. [Google Scholar]
  50. Lamand, M. , Tressol, J.C. and Bellanger, J. , 1994. The mineral and trace element composition in French food items and intake levels in France. J Trace Elem Electrolytes Health Dis 8, 195–202. [PubMed] [Google Scholar]
  51. Lane, H.W. , Strength, R. , Johnson, J. , White, M. , 1990. Effect of Chemical Form of Selenium on Tissue Glutathione Peroxidase Activity in Developing Rats. Journal of Nutrition 121, 80–86. [DOI] [PubMed] [Google Scholar]
  52. Larsen, E.H. , Hansen, M. , Paulin, H. , Moesgaard, S. , Reid, M. , Rayman, M. , 2004. Speciation and bioavailability of selenium yeast in yeast‐based intervention agents used in cancer chemoprevention studies. Journal of the Association of Official Analytical Chemists 87 (1), 225–232. [PubMed] [Google Scholar]
  53. Levander, O. , Alfthan, G. , Arvilommi, H. , Gref, C.G. , Huttunen, J.K. , Kataja, M. , Koivistoinen, P. , Pikkarainen, J. , 1983. Bioavailability of selenium to Finnish men as assessed by platelet glutathione peroxidase activity and other blood parameters. American Journal of Clinical Nutrition 37, 887–897. [DOI] [PubMed] [Google Scholar]
  54. Lobinski, R. , 2003. Selenium speciation in selenized yeast: comparison study. Report made to the petitioner PharmaNord, Appendix 2.4.13.4.a of the Technical Dossier.
  55. Longnecker, M.P. , Taylor, P.R. , Llevander, O.A. , Howe, S.M. , Veillon, C. , McAdam, P.A. , Patterson, K.Y. , Holden, J.M. , Stampfer, M.J. , Morris, J.S. , Willett, W.C. , 1991, Selenium in diet, blood and toenails in relation to human health in a seleniferous area. Am J Clin Nutr 53, 1288–94. [DOI] [PubMed] [Google Scholar]
  56. Longnecker, M.P. , Stampfer, M.J. , Morris, J.S. , Spate, V. , Baskett, C. , Mason, M. , Willett, W.C. , 1993, A l‐year trial of the effect of high‐selenium bread on selenium concentrations in blood and toenails. Am J Clin Nutr 57, 408–13. [DOI] [PubMed] [Google Scholar]
  57. Luo, X. , Quio, Ch , Liu, X. , Wei, H. , Feng, Y. , Guo, J. , Yang, Ch , Liu, J. , Stoeker, B.J. , 1987. Bioavailability of selenium to residents in a low‐selenium area of China. In: Selenium in Biology and Medicine, Part A. Combs, G.F. , Spallholz, J.E. , Levander, O.A. and Oldfield, eds., pp 436–444. Avi‐Van Nostrand Reinhold Company, New York, NY. [Google Scholar]
  58. Mahan, D.C. , Kim, Y.Y. , 1996. Effect of inorganic selenium at two dietary levels on reproductive performance and tissue selenium concentrations in first‐parity gilts and their progeny. Journal of Animal Science 74 (11), 2711–2718. [DOI] [PubMed] [Google Scholar]
  59. McAdam, P.A. and Levander, O.A. , 1987. Chronic toxicity of dietary selenium fed to rats as Dor L‐selenomethionine, selenite or selenate. Nutr. Res., 601–610.
  60. McGuire, M.K. , Burgert, S.L. , Milner, J.A. , Glass, L. , Kummer, R. , Deering, R. , Boucek, R. , Picciano, M.F. , 1993. Selenium status of lactating women is affected by the form of selenium consumed. American Journal of Clinical Nutrition 58, 649–652. [DOI] [PubMed] [Google Scholar]
  61. Ministry of Agriculture, Fisheries and Food , 1997. Food Surveillance Information Sheet no. 126, London: Joint Food Safety and Standards Group. [Google Scholar]
  62. Miyazaki, Y. , Koyama, H. , Hongo, T. , Sasada, Y. , Nojiri, M. and Suzuki, S. , 2001. Nutritional considerations for changes in dietary habit and health promotion practices in community health care; from the viewpoint of selenium (in Japanese with English abstract). Nippon Koshu Eisei Zasshi (Jpn J Pub Health) 48, 243–257. [PubMed] [Google Scholar]
  63. Moore, F.R. , Urda, G.A. , Krishna, G. , Theiss, J.C. , 1996. Genotoxicity evaluation of selenium sulfide in in vivo and in vivo/in vitro micronucleus and chromosome aberration assays. Mutat Res. 367: 33–41. [DOI] [PubMed] [Google Scholar]
  64. NAS , 2000. National Academy of Science Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids, National Academy Press, Washington, D.C: [PubMed] [Google Scholar]
  65. Nève, J. , 1995. Human selenium supplementation as assessed by changes in blood selenium concentration and glutathione peroxidase activity. J Trace Elem Med Biol. 9 (2), 65–73. [DOI] [PubMed] [Google Scholar]
  66. Norppa, H. , Westermarck, T. , Knuutila, S. , 1980. Chromosomal effects of sodium selenite in vivo. III. Aberrations and sister chromatid exchanges in Chinese hamster bone marrow. Hereditas, 93: 101–5. [PubMed] [Google Scholar]
  67. Ortman, K. , Pehrson, B. , 1999. Effect of selenate as a feed supplement to dairy cows in comparison to selenite and selenium yeast. J. Anim. Sci. 77, 3365–3370. [DOI] [PubMed] [Google Scholar]
  68. Patterson, B.H. , Levander, O.A. , Helzlsouer, K. , McAdam, P.A. , Lewis, S.A. , Taylor, P.R. , Veillon, C. and Zech, L.A. , 1989. Human selenite metabolism: a kinetic model. American Journal of Physiology 257, R556–R567. [DOI] [PubMed] [Google Scholar]
  69. Rayman, M.P. , 2002. PRECISE Pilot Study. Final Report (of the United Kingdom centre). University of Surrey.
  70. Rayman, M.P. , 2004. The use of high‐selenium yeast to raise selenium status: how does it measure up? British Journal of Nutrition 92, 557–573. [DOI] [PubMed] [Google Scholar]
  71. Reid, M.E. , Stratton, M.S. , Lillico, A.J. , Fakih, M. , Natarajan, R. , Clark, L.C. , Marshall, J.R. , 2004. A report of high‐dose selenium supplementation: response and toxicities. Journal of Trace Elements in Medicine and Biology 18: 69–74. [DOI] [PubMed] [Google Scholar]
  72. Reilly, C. , 1996. Selenium in food. Publisher Blackie Academic and Professional, pp 237–245. [Google Scholar]
  73. Robberecht, H.J. , Hendrix, P. , Van Cauenbergh, R. and Deelstra, H.A. , 1994. Actual daily intake of selenium in Belgium using duplicate portion sampling. Z Lebensm Unters Forsch 199, 251–254. [DOI] [PubMed] [Google Scholar]
  74. SCF , 1993. Reports of the Scientific Committee for Food (Thirty‐fourth series). Luxembourg: Office for Official Publications of the European Communities, 1995. [Google Scholar]
  75. SCF , 1994. Minutes of the 95th Meeting of SCF, 15–16 December 1994.
  76. SCF , 1999. Opinion on substances for nutritional purposes which have been proposed for use in the manufacture of foods for particular nutritional purposes (PARNUTS) (expressed on 12/5/99).
  77. SCF , 2000. Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Selenium (expressed on 19 October 2000).
  78. Schrauzer, G.N. , 2000. Selenomethionine: a review of its nutritional significance, metabolism and toxicity. J Nutr 130, 1653–1656. [DOI] [PubMed] [Google Scholar]
  79. Schrauzer, G.N. , 2003. The nutritional significance, metabolism and toxicology of selenomethionine. Advances in Food and Nutrition Research 47, 73–112. [DOI] [PubMed] [Google Scholar]
  80. Schrauzer, G.N. and White, D.A. , 1978. Selenium in human nutrition: dietary intakes and effects of supplementation. Bioinorganic Chemistry 8, 303–318. [DOI] [PubMed] [Google Scholar]
  81. Sima, A. and Pfannhauser, W. , 1998. Selenium levels in foods produced in Austria. In Mengen‐Spurenelem., Arbeitstag 18th, pp. 197–204 [M Anke, editors]. Leipsig: Verlag Harald Schubert.
  82. Sloth, J. , Larsen, E.H. , Bügel, S.H. , Moesgaard, S. , 2003. Determination of total selenium and 77Se in isotopically enriched human samples by ICP‐dynamic reaction cell‐MS. Journal of Analytical Atomic Spectrophotometry 18, 317–322. [Google Scholar]
  83. Spallholz, J.E. and Rafferty, A. , 1987. Nutritional, chemical and toxicological evaluation of high‐selenium yeast. In: Selenium in Biology and Medicine, Part A ( Combs, G.F. et al., eds.), pp. 516–529. Avi‐Van Nostrand Reinhold, New York, NY. [Google Scholar]
  84. Stratton, M.S. , Reid, M.E. , Schwartzberg, G. , Minter, F.E. , Monroe, B.K. , Alberts, D.S. , Marshall, J.R. , Ahmann, F.R. , 2003. Selenium and prevention of prostate cancer in high risk men: The negative biopsy study. Anticancer drugs 14, 595–600. [DOI] [PubMed] [Google Scholar]
  85. Sunde, R.A. , 1990. Molecular Biology of Selenoproteins. Annual Review of Nutrition 10, 451–474. [DOI] [PubMed] [Google Scholar]
  86. Swanson, C.A. , Patterson, B.H. , Levander, O.A. , Veillon, C. , Taylor, P.R. , Helzlsouer, K. , McAdam, P.A. and Zech L.A., 1991. Human [74Se]selenomethionine metabolism: a kinetic model. American Journal of Clinical Nutrition 54, 917–926. [DOI] [PubMed] [Google Scholar]
  87. Tarantal, A.F. , Willhite, C.C. , Lesley, B.L. , Murphy, C.J. , Miller, C.J. , Cukierski, M.J. , Book, S.A. and Hendrickx, A.G. , 1991. Developmental toxicity of L‐selenomethionine in Macaca fascicularis. Fund Appl Toxicol 16: 147–160. [DOI] [PubMed] [Google Scholar]
  88. Thomson, C.D. , Robinson, M.F. , Butler, J.A. and Whanger, P.D. , 1993. Long‐term supplementation with selenate and selenomethionine: selenium and glutathione peroxidase (EC 1.1 1.1.9) in blood components of New Zealand women. British Journal of Nutrition 69, 577–588. [DOI] [PubMed] [Google Scholar]
  89. Trafikowska, U. , Sobkowiak, E. , Butler, J.A. , Whanger, P.D. , Zachara, B.A. , 1998. Organic and inorganic selenium supplementation to lactating mothers increases the blood and milk Se concentrations and Se intake by breast‐fed infants. Journal of Trace Elements in Medicine and Biology 12, 77–85. [DOI] [PubMed] [Google Scholar]
  90. Uden, P.C. , Boakye, H.T. , Kahakachchi, C. , Hafezi, R. , Nolibos, P. , Block, E. , Johnson, S. , Tyson, J.F. , 2004. Elemental selective characterization of stability and reactivity of Selenium species in selenized yeast. J. Anal. At. Spectrom 19, 65–73. [Google Scholar]
  91. van Dokkum, W. , 1995. The intake of selected minerals and trace elements in European countries. Nutr Res Rev 8, 271–302. [DOI] [PubMed] [Google Scholar]
  92. Vannoort, R. , Cressey, P. and Silvers, K. , 2000. 1997/1998 New Zealand Total Diet Survey. Part 2: Elements. Wellington, New Zealand: Ministry of Health. [Google Scholar]
  93. Vinson, J.A. and Bose, P. , 1987. Comparison of the toxicity of inorganic and natural selenium. In Selenium in Medicine and Biology, Part A; eds Combs, G.F. Jr. et al., pp. 513–515. Van Nostrand Reinhold Company, New York. [Google Scholar]
  94. Wasowicz, W. , Gromadzinska, J. , Rydzynski, K. and Tomczak, J. , 2003. Selenium status of low‐selenium area residents: Polish experience. Toxicol Lett 137, 95–101. [DOI] [PubMed] [Google Scholar]
  95. Wolffram, S. , Berger, B. , Beat Grenacher, B. and Scharrer, E. , 1989. Transport of selenoamino acids and their sulfur analogues across the intestinal brush border membrane of pigs. Journal of Nutrition 119 (II), 706–712. [DOI] [PubMed] [Google Scholar]
  96. Xia, Y. , Zhao, X. , Zhu, L. , Whanger, P.D. , 1992. Metabolism of selenate and selenomethionine by a selenium deficient population of men from China. Journal of Nutrition & Biochemistry 3, 202–210. [Google Scholar]
  97. Whanger, P. , Venderland, S. , Park, Y.C. , Xia, Y. , 1996. Metabolism of sub toxic levels of Selenium in animals and humans. Annals of clinical and laboratory science Vol. 26, No 2, pp 99–114. [PubMed] [Google Scholar]
  98. Yang, G. , Wang, S. , Zhou, R. , Sun, S. , 1983. Endemic selenium intoxication of humans in China. Am J Clin Nutr 37, 872–81. [DOI] [PubMed] [Google Scholar]
  99. Yang G, Yin S, Zhou R, Gu L, Yan B, Liu Y, Liu Y, 1989. Studies of safe maximal daily dietary selenium intake in a seleniferous area in China. Part II. Relation between Se‐intake and the manifestation of clinical signs and certain biochemical alterations in blood and urine. Journal of Trace Elements & Electrolytes in Health & Disease 3 (3), 123–130. [PubMed] [Google Scholar]
  100. Yang, G. , Zhou, R. , 1994. Further observations on the human maximum safe dietary selenium intake in a seleniferous area of China. Journal of Trace Elements and Electrolytes in Health and Disease 8, 159–165. [PubMed] [Google Scholar]
  101. Yoshida M., Fukunaga, K. , Tsuchita, H. , Yasumoto, K. , 1999. An evaluation of the bioavailability of selenium in high‐selenium yeast. J Nutr Sci Vitaminol (Tokyo) 45 (1), 119–28. [DOI] [PubMed] [Google Scholar]
  102. Yu, S.Y. , Zhu, Y.J. , Li, W.G. , 1997. Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Biological Trace Element Research, Volume 56, Number 1, 117–124. [DOI] [PubMed] [Google Scholar]

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