Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 18;18:57. doi: 10.1186/s13020-023-00752-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Effects of XKY on transcriptomic profiling of the liver in db/db mice. Volcano plot of the DEGs of the NC group vs. Model group (A), XKY-H group vs. Model group (B). Red color, green color, and grey color points indicated the significantly upregulated genes, downregulated genes and not significantly changed genes respectively. The gray dashed horizontal line indicated the FDR < 0.05, and the gray perpendicular dotted line indicated the |log₂FC| > 0.5. C Venn diagrams showing the number of significantly DEGs in NC group vs. Model group and XKY-H group vs. Model group. D A cluster heatmap displays expression profiles of the significantly recovered DEGs by XKY-H treatment among the overlapped DEGs profiles in (C). E The top 20 of GO-biological process enrichment of the recovered DEGs profiles performed by DAVID online tool. F A cluster heatmap displays expression profiles of the recovered DEGs enriched in the cholesterol synthesis process. G Key DEGs (red text) involved in the process of cholesterol synthesis. (H) Relative mRNA expression of key DEGs involved in cholesterol synthesis process. Data were shown as means ± SD (n = 3, *P < 0.05, **P < 0.01, ***P < 0.001 vs. the Model group)