Table 2.
Common evaluation index of different POF animal models
| POF model | Body weight | Hormone | Biomarkers of granulosa cells | Fertility | The model from references | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMH | FSH | LH | E2 | Ki67 | Bcl2 | Bax | Caspase (3/9) | FSHR | Number of litters produced | |||
| CTX | / | ↓ | ↑ | ↑ | ↓ | ↓ | ↓ | ↑ | ↑ | ↓ | ↓ | [30, 33] |
| VCD | ↓ | ↓ | / | / | ↑/↓ | / | / | / | / | / | / | [31] |
| CIS | ns | / | / | / | ↓ | / | / | / | ↑ | / | / | [22] |
| DOX | / | / | / | / | / | / | / | / | ↑ | / | / | [11] |
| GAL | / | / | ↑ | / | ↓ | / | / | / | / | / | / | [18] |
| pZP3 | ↓ | ↓ | ↑ | ↑ | ↓ | / | / | / | / | ↓ | / | [35] |
| OA + FIA | ↓ | ↓ | / | / | ↓ | / | ↓ | / | ↑ | ↓ | / | [13] |
| HFHS | / | / | / | / | ↓ | / | / | / | / | ↓ | / | [37] |
| POF model | Ovary | Follicles count | The model from references | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ovary size | Ovary weight | Estrous cycle | Corpus luteum | Ovulation number | Abnormal ovulation | Pro-follicles | Pri-follicles | Snd-follicles | Antral follicle | Atresia follicle | Apoptotic follicles | ||
| CTX | / | ↓ | - | ↓ | ↓ | ↑ | ↓ | ↓ | ↓ | ↓ | ↑ | ↑ | [30, 33] |
| VCD | ↓ | / | - | / | / | / | ↓ | ↓ | ↓ | / | ↑ | / | [31] |
| CIS | / | / | / | / | / | / | ↓ | ↓ | ↓ | ↓ | / | / | [22] |
| DOX | ↓ | ↓ | / | / | / | / | ns | ns | ns | ns | ns | ns | [11] |
| GAL | / | / | / | / | / | / | / | / | / | ↓ | / | / | [18] |
| pZP3 | / | ↓ | - | / | / | / | ↓ | ↓ | / | ↓ | / | ↑ | [35] |
| OA + FIA | / | / | / | ↓ | / | / | ↓ | ↓ | ↓ | ↓ | ↑ | / | [13] |
| HFHS | / | / | / | / | / | / | / | / | / | ↓ | / | ↑ | [37] |
AMH anti-Müllerian hormone, FSH follicle-stimulating hormone, LH luteinizing hormone, E2 estrogen, BCL2 B cell lymphoma 2, BAX Bcl-2 associated X protein, VCD 4-vinylcyclohexene dicyclic oxide, pZP3 zona pellucida 3 peptides, CTX cyclophosphamide, Pro-follicles primordial follicles, Pri-follicles primary follicles, Snd-follicles secondary follicles. Galactose (GAL), HFHS: High-fat diet,↓:Down-regulation, ↑: Up-regulation, ns: No statistical difference, /: no report; -: Interruption