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Ferroptosis is modulated by autophagy. Enhanced GPX4 degradation mediated by CMA activation gives rise to lipid peroxidation and ferroptosis. The macro-autophagy activation induces ARNTL degradation, thus transcriptionally promotes the EGLN2 expression, and subsequently inhibits HIF1α-mediated lipid storage, finally leading to lipid peroxidation and ferroptosis.
