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. 2023 May 18;23:160. doi: 10.1186/s12906-023-03975-0

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Differentially expressed genes and their function enrichment analysis in cantharidin treated HepG2 cell. (A, B) volcano plot and heat map visualization of the differentially expressed genes after cantharidin treatments in HepG2. Red represents upregulation genes; green represents downregulation genes. (A) Volcano plot of genes. (B) Heat map of differentially expressed genes that logFC > 1, <-1, p < 0.05. (C) GO enrichment of differentially expressed genes. (D) The EMT related genes after cantharidin treatment HepG2 cell was screened using venn diagram. (E) PPI network of EMT related genes. (F) KEGG enrichment of the differentially expressed genes after cantharidin treatment in HepG2 cell. (G) Top 10 significantly enriched signaling pathways in cantharidin treated HepG2 cell