. Author manuscript; available in PMC: 2024 Jan 1.

Published in final edited form as: J Alzheimers Dis. 2023;92(3):887–898. doi: 10.3233/JAD-221015

Table 3.

Associations between CSF neurodegeneration biomarkers and Alzheimer’s and vascular pathology biomarkers using full linear high order and parsimonious models

	NfL						Neurogranin						T-Tau
	Full Models			Parsimonious Models			Full Models			Parsimonious Models			Full Models			Parsimonious Models
Predictors	Coefficient	P	Partial R ²	Coefficient	P	Partial R ²	Coefficient	P	Partial R ²	Coefficient	P	Partial R ²	Coefficient	P	Partial R ²	Coefficient	P	Partial R ²

(Intercept)	4.27	<0.001		4.29	<0.001		196.34	<0.001		212.29	<0.001		192.01	<0.001		181.62	<0.001
Age	0.02	<0.001	0.071	0.02	<0.001	0.12	−0.57	0.018	0.014	−0.76	<0.001	0.040	0.24	0.049	0.010	0.36	<0.001	0.033
Male	0.23	<0.001	0.045	0.23	<0.001	0.043	−14.46	<0.001	0.041	−13.60	<0.001	0.038	−0.30	0.862	<0.001
Aβ42	0.00	0.107	0.006				0.02	<0.001	0.064	0.02	<0.001	0.071	0.02	<0.001	0.14	0.02	<0.001	0.13
PTAU	0.02	<0.001	0.071	0.02	<0.001	0.078	1089.51	<0.001	0.67	1090.84	<0.001	0.67	1697.55	<0.001	0.95	1696.59	<0.001	0.95
PTAU²							−270.01	<0.001		−273.84	<0.001		−110.86	<0.001		−109.15	<0.001
PC1^*	0.05	0.412	0.002				−5.15	0.162	0.005				3.03	0.097	0.007
PC3^†	0.09	0.009	0.017	0.10	0.002	0.023	1.28	0.550	<0.001				2.26	0.034	0.011	2.50	0.018	0.014
PC3^*Male													4.30	0.035	0.011

N	408			408			408			408			408			408
R²	0.341			0.336			0.727			0.726			0.963			0.963

PC1 is a weighted sum of WMH score and White Matter Integrity (FA-GCC) score.

^†

PC3 is based on total number of infarcts.

Abbreviations: NfL, neurofilament light chain; t-tau, total tau. P-tau, phosphorylated tau.