Table 4.

Cognitive impairment-stratified models (Aβ42 age-adjusted)

	Neurogranin (CU)		Neurogranin (Impaired)		NfL (CU)		NfL (Impaired)		T-Tau (CU)		T-Tau (Impaired)
Predictors	Coefficient	P	Coefficient	P	Coefficient	P	Coefficient	P	Coefficient	P	Coefficient	P
(Intercept)	8.06	0.730	13.72	0.890	3.85	<0.001	5.13	<0.001	−95.33	0.001	−75.06	0.647
Aβ42	0.06	<0.001	0.01	0.620	0.0003	<0.001	−0.0004	0.080	0.07	<0.001	−0.02	0.606
Age	1.48	<0.001	2.26	0.070	0.03	<0.001	0.02	0.063	3.55	<0.001	4.74	0.022
Observations	359		49		359		49		359		49
R2	0.182		0.070		0.256		0.159		0.265		0.128

CU (n=359), Impaired (n=49)

Abbreviations: CU, cognitively unimpaired; NfL, neurofilament light chain; t-tau, total tau.