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. 2023 May 17;18(1):2214047. doi: 10.1080/15592294.2023.2214047

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — Proposed mechanism of chronic DNA damage on cell metabolism. Repeated DNA damage over time results in depletion of NAD+ due to the action of PARP1. The cell then compensates for this by attempting to increase TCA intermediates. The roles of ASNS and OGDHL are highlighted.