Table 4:

Comparisons of NGF metabolic pathway proteins in frontal cortex between individuals classified LA-NCI (n = 43), HA-NCI (n = 16), MCI (n = 20), and AD (n = 19).

Species	LA-NCI vs HA-NCI	LA-NCI vs. MCI	LA-NCI vs AD	Overall
NGF mRNA	n.s.	n.s.	n.s.	df=3,95; H = 2.4; p > 0.05
NGF protein	rs = 8.842, p = 0.06	rs = 15.73, p < 0.01	rs = 17.14, p < 0.01	df = 2,52; H = 14.38; p < 0.01
proNGF 27 kDa	t=4.095, p < 0.001	t = 7.058, p < 0.001	t = 4.984 p < 0.001	df = 3,95; F = 19.96; p < 0.0001
proNGF 41 kDa	t = 3.795, p < 0.001	t = 5.399, p < 0.001	t = 4.035, p < 0.001	df = 3,95; F = 12.68; p < 0.0001
Plasminogen mRNA	n.s	n.s	n.s	df = 3,95; H = 0.87; p > 0.05
Plasminogen protein	t = 2.605, p < 0.05	t = 4.035, p < 0.001	t = 3.070 p < 0.01	df = 3,95; F = 26.80; p < 0.0001
tPA mRNA	rs = 22.37, p < 0.05	n.s	n.s	df = 3,95; H = 7.652; p = 0.05
tPA protein	rs = 23.46, p < 0.05	n.s	n.s	df = 3,95; H = 8.754, p < 0.05
Neuroserpin mRNA	n.s	rs = 30.91, p < 0.001	rs = 22.26, p < 0.05	df = 3,95; H = 29.23; p < 0.0001
Neuroserpin protein	n.s	rs = −34.41, p < 0.001	rs = −33.39 p < 0.001	df = 3,95; H = 30.18; p < 0.0001
MMP9 mRNA	n.s	rs = 26.67, p < 0.001	rs = 28.63, p < 0.001	df = 3,95; H = 25.44; p < 0.0001
MMP9 activity	n.s	rs = 27.55, p < 0.001	rs = 33.91 p < 0.001	df = 3,95; H = 29.33; p < 0.0001
proMMP9 activity	n.s	rs = 27.55, p < 0.001	t = 33.91 p < 0.001	df = 3,95; H = 29.33; p < 0.0001
TIMP1 mRNA	n.s	rs = 18.90, p < 0.05	rs = 26.40, p < 0.01	df = 3,95; H = 15.03; p < 0.01

Results of ANOVA/Kruskal-Wallis comparison and Bonferroni/Dunn’s post-hoc tests are reported.