Table 5.
Bivariate predictors of timing preferences of cancer predisposition testing and expanded carrier screening.
| Characteristics | Cancer predisposition testing |
p-value | Expanded carrier screening |
p-value | ||||
|---|---|---|---|---|---|---|---|---|
| When planning for a pregnancy |
During/After pregnancy |
Not sure/Should not be offered |
When planning for a pregnancy |
During/After pregnancy |
Not sure/Should not be offered |
|||
|
n = 246 |
n = 65 |
n = 40 |
n = 244 |
n = 70 |
n = 37 |
|||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||
| Pregnancy status | 0.24 | 0.14 | ||||||
| Had a prior pregnancy | 210 (85.4) | 51 (78.5) | 36 (90.0) | 210 (86.1) | 54 (77.1) | 33 (89.2) | ||
| Currently pregnant | 36 (14.6) | 14 (21.5) | 4 (10.0) | 34 (13.9) | 16 (22.9) | 4 (10.8) | ||
| High importance of cancer genetic information | 148 (60.2) | 29 (44.6) | 19 (47.5) | 0.043 | 149 (61.1) | 33 (47.1) | 14 (37.8) | 0.008 |
| High importance of carrier status information | 194 (78.9) | 37 (56.9) | 22 (55.0) | <0.001 | 190 (77.9) | 45 (64.3) | 18 (48.6) | <0.001 |
| Risk perception (Somewhat more likely/a lot more likely) | ||||||||
| Breast cancer | 91 (37.0) | 31 (47.7) | 16 (40.0) | 0.29 | 91 (37.3) | 34 (48.6) | 13 (35.1) | 0.20 |
| Ovarian cancer | 98 (39.8) | 25 (38.5) | 9 (22.5) | 0.11 | 98 (40.2) | 25 (35.7) | 9 (24.3) | 0.17 |
| Colon cancer | 41 (16.7) | 14 (21.5) | 8 (20.0) | 0.62 | 45 (18.4) | 14 (20.0) | 4 (10.8) | 0.47 |
| Strongly agree that the people who mean the most to me think | ||||||||
| I should learn more about ways I can keep myself healthy | 79 (32.1) | 22 (33.8) | 8 (20.0) | 0.27 | 79 (32.4) | 24 (34.3) | 6 (16.2) | 0.11 |
| I should learn more about genetic testing | 39 (15.9) | 19 (29.2) | 7 (17.5) | 0.047 | 37 (15.2) | 23 (32.9) | 5 (13.5) | 0.003 |
| Very motivated to do what these people want me to do regarding | ||||||||
| Keeping myself healthy | 103 (41.9) | 21 (32.3) | 9 (22.5) | 0.038 | 97 (39.8) | 28 (40.0) | 8 (21.6) | 0.10 |
| Genetic testing | 64 (26.0) | 17 (26.2) | 6 (15.0) | 0.31 | 59 (24.2) | 24 (34.3) | 4 (10.8) | 0.026 |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |||
|---|---|---|---|---|---|---|---|---|
| Genetic worry | 5.4 (1.5) | 5.4 (1.2) | 4.5 (1.6) | 0.001 | 5.4 (1.5) | 5.4 (1.4) | 4.4 (1.6) | <0.001 |
| Genetic knowledge | 12.8 (2.9) | 11.6 (3.1) | 10.3 (3.7) | <0.001 | 12.7 (2.9) | 11.7 (3.0) | 10.1 (4.0) | <0.001 |
| Attitude toward uncertainty | 4.1 (0.7) | 3.7 (0.8) | 3.6 (0.8) | <0.001 | 4.1 (0.7) | 3.8 (0.7) | 3.4 (0.7) | <0.001 |
| Coping efficacy | 3.9 (0.7) | 3.8 (0.7) | 3.7 (0.7) | 0.027 | 4.0 (0.7) | 3.9 (0.7) | 3.4 (0.8) | <0.001 |
| Health orientation | 4.1 (0.6) | 4.0 (0.6) | 3.9 (0.7) | 0.06 | 4.1 (0.6) | 4.1 (0.5) | 3.7 (0.8) | <0.001 |
| Partner emotional support | 4.2 (0.7) | 3.9 (0.7) | 3.7 (0.9) | 0.001 | 4.2 (0.8) | 4.0 (0.6) | 3.7 (0.6) | 0.007 |
| Descriptive norms | 5.1 (1.4) | 5.1 (1.5) | 4.5 (1.5) | 0.07 | 5.0 (1.5) | 5.3 (1.4) | 4.5 (1.5) | 0.019 |
| Patient-provider trust | 5.5 (2.6) | 5.5 (2.4) | 3.3 (3.3) | <0.001 | 5.4 (2.7) | 5.1 (2.7) | 4.2 (3.0) | 0.030 |
| Numeracy preference | 4.6 (1.1) | 4.4 (1.0) | 4.1 (1.2) | 0.042 | 4.6 (1.1) | 4.5 (1.1) | 4.0 (1.1) | 0.017 |
| Numeracy Ability | 3.9 (1.3) | 4.0 (1.4) | 3.4 (1.5) | 0.06 | 3.9 (1.4) | 4.0 (1.5) | 3.6 (1.4) | 0.35 |
| Health literacy | 8.3 (2.0) | 9.1 (2.7) | 8.7 (2.3) | 0.034 | 8.4 (1.9) | 9.1 (2.9) | 8.4 (1.9) | 0.06 |
Bold p-values indicate p < 0.05; SD - Standard Deviation; p-value by ANOVA or Chi-Square test