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. Author manuscript; available in PMC: 2023 May 18.
Published in final edited form as: Toxicol Sci. 2021 Apr 27;181(1):68–89. doi: 10.1093/toxsci/kfab009

Figure 4. Signature set enrichment of reference chemical treatments.

Figure 4.

(A) Distributions of absolute ssGSEA signature scores, calculated from the DESeq2 moderated log2 fold changes across the three test plates, for specific molecular target signatures across each treatment group. (B) Table of the top 5 highest ranked signatures by absolute signature score for Genistein (red), Sirolimus (green), or Trichostatin A (blue). GEN = Genistein; SIRO = Sirolimus; TSA = Trichostatin A; NULL = 1000 simulated chemicals derived from the null distribution (see methods).