Table 1:
Chemicals used in the study
| Name | CASRN | Target annotation |
|---|---|---|
| Cyproterone acetate | 427-51-0 | AR antagonist |
| Flutamide | 13311-84-7 | AR antagonist |
| Nilutamide | 63612-50-0 | AR antagonist |
| Vinclozolin | 50471-44-8 | AR antagonist |
| Amiodarone hydrochloride | 19774-82-4 | Blocks myocardial calcium, potassium and sodium channels |
| Cladribine | 4291-63-8 | DNA synthesis inhibitor |
| 4-Cumylphenol | 599-64-4 | ER agonist |
| 4-Nonylphenol, branched | 84852-15-3 | ER agonist |
| Bisphenol A | 80-05-7 | ER agonist |
| Bisphenol B | 77-40-7 | ER agonist |
| 4-Hydroxytamoxifen | 68392-35-8 | ER antagonist |
| Clomiphene citrate (1:1) | 50-41-9 | ER antagonist |
| Fulvestrant | 129453-61-8 | ER antagonist |
| Cyproconazole | 94361-06-5 | Ergosterol-biosynthesis inhibitor. Pan-cyp inhibitor |
| Imazalil | 35554-44-0 | Ergosterol-biosynthesis inhibitor. Pan-cyp inhibitor |
| Prochloraz | 67747-09-5 | Ergosterol-biosynthesis inhibitor. Pan-cyp inhibitor |
| Propiconazole | 60207-90-1 | Ergosterol-biosynthesis inhibitor. Pan-cyp inhibitor |
| Atrazine | 1912-24-9 | Herbicide, photosystem II inhibitor |
| Cyanazine | 21725-46-2 | Herbicide, photosystem II inhibitor |
| Simazine | 122-34-9 | Herbicide, photosystem II inhibitor |
| Butafenacil | 134605-64-4 | Herbicide, protoporphyrinogen oxidase (PPO) inhibition |
| Fomesafen | 72178-02-0 | Herbicide, protoporphyrinogen oxidase (PPO) inhibition |
| Lactofen | 77501-63-4 | Herbicide, protoporphyrinogen oxidase (PPO) inhibition |
| Lovastatin | 75330-75-5 | HMGCR inhibitor |
| Simvastatin | 79902-63-9 | HMGCR inhibitor |
| Maneb | 12427-38-2 | Inhibition of metal-dependent and sulfhydryl enzyme systems |
| Thiram | 137-26-8 | Inhibition of metal-dependent and sulfhydryl enzyme systems |
| Ziram | 137-30-4 | Inhibition of metal-dependent and sulfhydryl enzyme systems |
| Reserpine | 50-55-5 | inhibition of the ATP/Mg2+ pump |
| Rotenone | 83-79-4 | Mitochondria (complex I inhibitor) |
| Pyraclostrobin | 175013-18-0 | Mitochondria (complex III inhibitor) |
| Trifloxystrobin | 141517-21-7 | Mitochondria (complex III inhibitor) |
| Fenpyroximate (Z,E) | 111812-58-9 | Mitochondrial electron transport inhibitor |
| Clofibrate | 637-07-0 | PPARα agonist, upregulates extrahepatic lipoprotein lipase |
| Fenofibrate | 49562-28-9 | PPARα agonist, upregulates extrahepatic lipoprotein lipase |
| Farglitazar | 196808-45-4 | PPARα agonist |
| PFOA | 335-67-1 | PPARα, PPARα agonist |
| PFOS | 1763-23-1 | PPARα, PPARα agonist |
| Troglitazone | 97322-87-7 | PPARα, PPARα agonist |
| Cycloheximide | 66-81-9 | Protein synthesis inhibitor |
| Bifenthrin | 82657-04-3 | Sodium channel modulator |
| Cypermethrin | 52315-07-8 | Sodium channel modulator |
| Tetrac | 67-30-1 | T4 synthesis inhibitor |
| 3,5,3’-Triiodothyronine | 2/3/6893 | Thyroid hormone receptor agonist |