Table 4. Serum DDX43 protein levels and its mRNA expression in malignant breast cancer patients subgroups according to some pathological parameters.
| Characteristics | Serum DDX43 protein levels (ng/L) (mean ± SD) | P-value | mRNA expression of DDX43 (mean ± SD) |
P-value |
|---|---|---|---|---|
| Pathological parameters | ||||
|
Tumor size (continuous) (n) T1 (<2 cm) (10) vs. T2 (2–5 cm) (22) T2 (2–5 cm) (22) vs. T3-4 (>5 cm) (27) T1 (<2 cm) (10) vs. T3-4 (>5 cm) (27) |
1294±1024.64 2783.5±2317.01 2783.5±2317.01* 1333.9±825.99 |
0.058 0.039 |
2.28±2.14 1.24±1.57 2.28±2.14 1.40±1.74 |
0.110 0.141 |
|
Tumor type (n) IDC (36) vs. ILC (8) IDC (36) vs. ICC (5) ILC (8) vs. ICC (5) |
1177±934.84* 2103.1±936.43 1177±934.84* 4955±4284.34 2103.1±936.43 4955±4284.34 |
0.042 0.006 0.152 |
||
|
Mitosis score (n) 1 (7) vs. 2 (44) 2 (44) vs. 3 (9) 1 (7) vs. 3 (9) |
2271.8±1948.29 1142.1±870.3 |
0.137 |
0.67±0.88 1.67±1.93 0.67±0.88 1.29±1.34 |
0.129 0.108 |
|
Nuclear grade (n) 2 (40) 3 (16) |
2252.1±1944.33 1273.1±1167.98 |
0.088 |
1.22±1.36 2.3±2.55 |
0.085 |
|
Tumor grade (n) Grade 2 (36) vs. grade 3 (17) Grade 1 (7) vs. grade 3 (17) |
|
1.3±1.62 2.06±2.17* 0.86±0.82 2.06±2.17 |
0.037 0.056 |
|
|
Hormonal receptors Estrogen receptor (n) Negative (9) Positive (51) |
|
2.07±2.21 1.36±1.66 |
0.168 |
|
|
Triple-negative phenotype (n) No (53) Yes (7) |
|
|
1.35±1.63 2.36±2.47 |
0.187 |