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AFB1 significantly induces reciprocal translocations in metabolically competent YB110 transformants. YB110 cells expressing CYP1A1 (□) or CYP1A2 (Δ), in combination with hOR or expressing no human cDNA (○), were exposed to 250 μM AFB1 at indicated times. His+ recombinants and survivors were quantitated on appropriate media (see “Materials and Methods”). Translocation frequencies are given as the ratio of His+ clones per survivors.
