Table 1.

Echocardiogram measurements in B10.WT and D2.WT mice.

	B10.WT	D2.WT
Heart rate (bpm)	463.24 ± 11.94	429.13 ± 15.22
LVAW;s (mm)	1.78 ± 0.09	2.03 ± 0.10
LVAW;d (mm)	1.17 ± 0.05	1.33 ± 0.08
LVPW;s (mm)	1.72 ± 0.09	1.81 ± 0.06
LVPW;d (mm)	1.18 ± 0.09	1.25 ± 0.06
EDD (mm)	3.65 ± 0.06	3.80 ± 0.15
ESD (mm)	2.08 ± 0.07	2.07 ± 0.16
EDV (μL)	56.29 ± 2.19	63.43 ± 6.07
ESV (μL)	14.23 ± 1.23	15.04 ± 2.87
SV (μL)	42.06 ± 2.13	48.39 ± 3.59
CO (mL/min)	19.44 ± 0.94	20.47 ± 1.20
EF (%)	74.64 ± 2.16	77.69 ± 2.43
FS (%)	42.93 ± 1.98	46.24 ± 2.26
MV E (mm/s)	699.35 ± 18.17	729.24 ± 19.10
MV A (mm/s)	597.93 ± 36.53	534.13 ± 22.66
MV E/A	1.19 ± 0.07	1.39 ± 0.07
AET (ms)	47.75 ± 1.13	46.48 ± 1.32
IVCT (ms)	12.31 ± 1.08	10.34 ± 1.18
IVRT (ms)	15.79 ± 0.50	16.41 ± 1.02
LV MPI IV	0.59 ± 0.02	0.58 ± 0.04

Cardiac function was assessed in 12-month-old D2.WT (n = 10) and B10.WT (n = 6) mice using LV short axis m-mode images and pulsed-wave Doppler of the flow through the mitral valve. Heart Rate (beats per second, BPM), LVAW; s (LV anterior wall thickness during systole, mm), LVAW;d (LV anterior wall thickness during diastole, mm), LVPW;s (LV posterior wall thickness during systole, mm), LVPW;d (LV posterior wall thickness during diastole, mm), EDD (end diastolic diameter, mm), ESD (end systolic diameter, mm), EDV (end diastolic volume, μL), ESV (end systolic volume, μL), SV (stroke volume, μL), CO (cardiac output, mL/min), EF (ejection fraction, %), FS (fractional shortening, %), MV E (mitral valve early flow velocity, mm/s), MV A (MV atrial flow velocity, mm/s), MV E/A (MV early/late flow ratio), AET (aortic ejection time, ms), IVRT (isovolumic relaxation time, ms), IVCT (isovolumic contraction time, ms), LV MPI IV (LV myocardial performance index, isovolumic). Data were analyzed using student’s t-test and no significance was found.