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. Author manuscript; available in PMC: 2023 May 18.
Published in final edited form as: Sci Signal. 2023 Mar 14;16(776):eabo2838. doi: 10.1126/scisignal.abo2838

Fig. 4. Simulation of canonical (IKK-mediated) pathway activation at different basal levels of NIK activity.

Fig. 4.

(A) The physiological IKK activity curve used as input for all heatmaps. (B) Surface plot of RelA:p50 (A:50) abundance (A) in simulations with a physiological IKK activity curve and the indicated NIK abundances. (C) Heatmaps of the nuclear concentrations of the indicated NF-κB dimers in simulations with a physiological IKK activity curve and the indicated NIK abundances.